CUT&RUN, or Cleavage Under Targets & Release Using Nuclease, is a protein-DNA interaction analysis technology that combines antibody-based targeting and micrococcal nuclease with qPCR or next-generation sequencing (NGS) to identify DNA binding sites of protein-DNA complexes. CUT&RUN can address the practical and cost-related limitations of ChIP-seq.
|In Vitro Protein-DNA Interaction|
Measurement of direct interactions between protein and DNA in vitro has an advantage in analyzing the binding of different transcription factors to specific DNA consensus sequences located in the gene promoters. By investigating protein-DNA interaction in vitro, it is possible to identify the genetic targets of DNA, which leads to a better understanding of cellular processes.
Featured Areas of Study
DNA, Protein, & Chromatin Preparation
DNA Methylation & Demethylation Analysis
Histone Methylation & Demethylation
Histone Acetylation & Deacetylation
Gene Expression & Silencing
DNA Damage & Repair
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